P-68: The Effect of Gundilia Tournefortii Leaf on Reproductive Physiology in Adult Male Rats

Background: The Gundilia tournefortii leaf contains the chemical compound such as saturated and unsaturated fatty acids. Saturated fatty acid includes stearic and palmitic acid and unsaturated include linoleic and oleic acid, that, these compounds inhibit 5 reductase enzyme. The present study was carried out with the aim of determining the effect of Gundilia tournefortii leaf on spermatogenesis and testosterone level in adult male rats. Materials and Methods: In this experimental research 45 male rats Wistar strain were divided into 5 group of nine including the control group received nothing, the sham group received an equal volume of ethanol as a solvent and the treatment groups received 200 , 400 and 600 mg/kg B.W of Gundilia tournefortii leaf alcoholic extract for 21 days orally. The results were analyzed through Excel, one- way analysis variance and t test. Results: The results showed 400 and 600 mg/kg of the extract increased testosterone level and sperm condense in seminiferous tubules and dihydro testosterone level reduced in comparison to the control and saline groups, while it had no significant effect on serum FSH and LH levels. Conclusion: According to the research results it can be stated that the extract of Gundilia tournefortii leaf has probably caused increasing testosterone level and decreasing dihydro testosterone level via inhibiting 5 reductase enzymes that effect by palmitic, stearic, linoleic and oleic acid of the pit.